For a complete list of publications click here.

 

Probing the lithium-response pathway in hiPSCs implicates the phosphoregulatory set-point for a cytoskeletal modulator in bipolar pathogenesis.

Tobe BTD, Crain AM, Winquist AM, Calabrese B, Makihara H, Zhao WN, Lalonde J, Nakamura H, Konopaske G, Sidor M, Pernia CD, Yamashita N, Wada M, Inoue Y, Nakamura F, Sheridan SD, Logan RW, Brandel M, Wu D, Hunsberger J, Dorsett L, Duerr C, Basa RCB, McCarthy MJ, Udeshi ND, Mertins P, Carr SA, Rouleau GA, Mastrangelo L, Li J, Gutierrez GJ, Brill LM, Venizelos N, Chen G, Nye JS, Manji H, Price JH, McClung CA, Akiskal HS, Alda M, Chuang DM, Coyle JT, Liu Y, Teng YD, Ohshima T, Mikoshiba K, Sidman RL, Halpain S, Haggarty SJ, Goshima Y, Snyder EY.

Proc Natl Acad Sci U S A. 2017 May 30;114(22):E4462-E4471. doi: 10.1073/pnas.1700111114. Epub 2017 May 12.

 

MeCP2-regulated miRNAs control early human neurogenesis through differential effects on ERK and AKT signaling.

Mellios N, Feldman DA, Sheridan SD, Ip JPK, Kwok S, Amoah SK, Rosen B, Rodriguez BA, Crawford B, Swaminathan R, Chou S, Li Y, Ziats M, Ernst C, Jaenisch R, Haggarty SJ, Sur M.

Mol Psychiatry. 2017 Apr 25. doi: 10.1038/mp.2017.86. [Epub ahead of print]

 

Classics in Chemical Neuroscience: Ketamine.

Tyler MW, Yourish HB, Ionescu DF, Haggarty SJ.

ACS Chem Neurosci. 2017 Apr 21. doi: 10.1021/acschemneuro.7b00074. [Epub ahead of print]

 

Development of [18F]Maleimide-Based Glycogen Synthase Kinase-3β Ligands for Positron Emission Tomography Imaging.

Hu K, Patnaik D, Collier TL, Lee KN, Gao H, Swoyer MR, Rotstein BH, Krishnan HS, Liang SH, Wang J, Yan Z, Hooker JM, Vasdev N, Haggarty SJ, Ngai MY.

ACS Med Chem Lett. 2017 Feb 2;8(3):287-292. doi: 10.1021/acsmedchemlett.6b00405. eCollection 2017 Mar 9.

 

Classics in Chemical Neuroscience: Haloperidol.

Tyler MW, Zaldivar-Diez J, Haggarty SJ.

ACS Chem Neurosci. 2017 Mar 15;8(3):444-453. doi: 10.1021/acschemneuro.7b00018. Epub 2017 Feb 15.

 

Highly Expandable Human iPS Cell-Derived Neural Progenitor Cells (NPC) and Neurons for Central Nervous System Disease Modeling and High-Throughput Screening.

Cheng C, Fass DM, Folz-Donahue K, MacDonald ME, Haggarty SJ.

Curr Protoc Hum Genet. 2017 Jan 11;92:21.8.1-21.8.21. doi: 10.1002/cphg.33.

 

Diversity-Oriented Synthesis as a Strategy for Fragment Evolution against GSK3β.

Wang Y, Wach JY, Sheehan P, Zhong C, Zhan C, Harris R, Almo SC, Bishop J, Haggarty SJ, Ramek A, Berry KN, O’Herin C, Koehler AN, Hung AW, Young DW.

ACS Med Chem Lett. 2016 Jul 14;7(9):852-6. doi: 10.1021/acsmedchemlett.6b00230. eCollection 2016 Sep 8.

 

Activity-dependent Regulation of Histone Lysine Demethylase KDM1A by a Putative Thiol/Disulfide Switch.

Ricq EL, Hooker JM, Haggarty SJ.

J Biol Chem. 2016 Nov 18;291(47):24756-24767. Epub 2016 Sep 15.

 

Human iPSC-Derived Neuronal Model of Tau-A152T Frontotemporal Dementia Reveals Tau-Mediated Mechanisms of Neuronal Vulnerability.

Silva MC, Cheng C, Mair W, Almeida S, Fong H, Biswas MH, Zhang Z, Huang Y, Temple S, Coppola G, Geschwind DH, Karydas A, Miller BL, Kosik KS, Gao FB, Steen JA, Haggarty SJ.

Stem Cell Reports. 2016 Sep 13;7(3):325-40. doi: 10.1016/j.stemcr.2016.08.001. Epub 2016 Sep 1.

 

Insights into neuroepigenetics through human histone deacetylase PET imaging.

Wey HY, Gilbert TM, Zürcher NR, She A, Bhanot A, Taillon BD, Schroeder FA, Wang C, Haggarty SJ, Hooker JM.

Sci Transl Med. 2016 Aug 10;8(351):351ra106. doi: 10.1126/scitranslmed.aaf7551.

 

Toward development of epigenetic drugs for central nervous system disorders: Modulating neuroplasticity via H3K4 methylation.

Ricq EL, Hooker JM, Haggarty SJ.

Psychiatry Clin Neurosci. 2016 Dec;70(12):536-550. doi: 10.1111/pcn.12426. Epub 2016 Sep 7. Review.

 

Functional analysis of rare variants found in schizophrenia implicates a critical role for GIT1-PAK3 signaling in neuroplasticity.

Kim MJ*, Biag J*, Fass DM*, Lewis MC, Zhang Q, Fleishman M, Gangwar SP, Machius M, Fromer M, Purcell SM, McCarroll SA, Rudenko G, Premont RT, Scolnick EM, Haggarty SJ.

Mol Psychiatry. 2017 Mar;22(3):417-429. doi: 10.1038/mp.2016.98. Epub 2016 Jul 26.

(* equal contribution)

 

Kinetic and structural insights into the binding of histone deacetylase 1 and 2 (HDAC1, 2) inhibitors.

Wagner FF, Weïwer M, Steinbacher S, Schomburg A, Reinemer P, Gale JP, Campbell AJ, Fisher SL, Zhao WN, Reis SA, Hennig KM, Thomas M, Müller P, Jefson MR, Fass DM, Haggarty SJ, Zhang YL, Holson EB.

Bioorg Med Chem. 2016 Sep 15;24(18):4008-15. doi: 10.1016/j.bmc.2016.06.040. Epub 2016 Jun 22.

 

Discovery of a Highly Selective Glycogen Synthase Kinase-3 Inhibitor (PF-04802367) That Modulates Tau Phosphorylation in the Brain: Translation for PET Neuroimaging.

Liang SH, Chen JM, Normandin MD, Chang JS, Chang GC, Taylor CK, Trapa P, Plummer MS, Para KS, Conn EL, Lopresti-Morrow L, Lanyon LF, Cook JM, Richter KE, Nolan CE, Schachter JB, Janat F, Che Y, Shanmugasundaram V, Lefker BA, Enerson BE, Livni E, Wang L, Guehl NJ, Patnaik D, Wagner FF, Perlis R, Holson EB, Haggarty SJ, El Fakhri G, Kurumbail RG, Vasdev N.

Angew Chem Int Ed Engl. 2016 Aug 8;55(33):9601-5. doi: 10.1002/anie.201603797. Epub 2016 Jun 29.

 

Inhibitors of Glycogen Synthase Kinase 3 with Exquisite Kinome-Wide Selectivity and Their Functional Effects.

Wagner FF, Bishop JA, Gale JP, Shi X, Walk M, Ketterman J, Patnaik D, Barker D, Walpita D, Campbell AJ, Nguyen S, Lewis M, Ross L, Weïwer M, An WF, Germain AR, Nag PP, Metkar S, Kaya T, Dandapani S, Olson DE, Barbe AL, Lazzaro F, Sacher JR, Cheah JH, Fei D, Perez J, Munoz B, Palmer M, Stegmaier K, Schreiber SL, Scolnick E, Zhang YL, Haggarty SJ, Holson EB, Pan JQ.

ACS Chem Biol. 2016 Jul 15;11(7):1952-63. doi: 10.1021/acschembio.6b00306. Epub 2016 May 13.

 

Diagnostic and therapeutic potential of microRNAs in neuropsychiatric disorders: Past, present, and future.

Alural B, Genc S, Haggarty SJ.

Prog Neuropsychopharmacol Biol Psychiatry. 2017 Feb 6;73:87-103. doi: 10.1016/j.pnpbp.2016.03.010. Epub 2016 Apr 9.

 

Stem cell models of neuropsychiatric disorders.

Karmacharya R, Haggarty SJ.

Mol Cell Neurosci. 2016 Jun;73:1-2. doi: 10.1016/j.mcn.2016.03.007. Epub 2016 Mar 21. No abstract available.

 

Light-controlled modulation of gene expression by chemical optoepigenetic probes.

Reis SA*, Ghosh B*, Hendricks JA, Szantai-Kis DM, Törk L, Ross KN, Lamb J, Read-Button W, Zheng B, Wang H, Salthouse C, Haggarty SJ, Mazitschek R.

Nat Chem Biol. 2016 May;12(5):317-23. doi: 10.1038/nchembio.2042. Epub 2016 Mar 14.

(* equal contribution)

 

Advancing drug discovery for neuropsychiatric disorders using patient-specific stem cell models.

Haggarty SJ, Silva MC, Cross A, Brandon NJ, Perlis RH.

Mol Cell Neurosci. 2016 Jun;73:104-15. doi: 10.1016/j.mcn.2016.01.011. Epub 2016 Jan 28. Review.

 

Dissecting structure-activity-relationships of crebinostat: Brain penetrant HDAC inhibitors for neuroepigenetic regulation.

Ghosh B*, Zhao WN*, Reis SA, Patnaik D, Fass DM, Tsai LH, Mazitschek R, Haggarty SJ.

Bioorg Med Chem Lett. 2016 Feb 15;26(4):1265-71. doi: 10.1016/j.bmcl.2016.01.022. Epub 2016 Jan 11.

(* equal contribution)

 

A high-throughput kinome screen reveals serum/glucocorticoid-regulated kinase 1 as a therapeutic target for NF2-deficient meningiomas.

Beauchamp RL, James MF, DeSouza PA, Wagh V, Zhao WN, Jordan JT, Stemmer-Rachamimov A, Plotkin SR, Gusella JF, Haggarty SJ, Ramesh V.

Oncotarget. 2015 Jul 10;6(19):16981-97.

 

Noncoding RNAs connect genetic risk factors to the neurodevelopmental basis of bipolar disorder.

Bavamian S, Mellios N, Lalonde J, Fass DM, Wang J, Sheridan SD, Madison JM, Zhou F, Rueckert EH, Barker D, Perlis RH, Sur M, Haggarty SJ.

Mol Psychiatry. 2015 May;20(5):548. doi: 10.1038/mp.2015.51. No abstract available.

 

Unbiased Cell-based Screening in a Neuronal Cell Model of Batten Disease Highlights an Interaction between Ca2+ Homeostasis, Autophagy, and CLN3 Protein Function.

Chandrachud U, Walker MW, Simas AM, Heetveld S, Petcherski A, Klein M, Oh H, Wolf P, Zhao WN, Norton S, Haggarty SJ, Lloyd-Evans E, Cotman SL.

J Biol Chem. 2015 Jun 5;290(23):14361-80. doi: 10.1074/jbc.M114.621706. Epub 2015 Apr 15.