Design, discovery, and optimization of small molecules is the name of the game. How is regeneration from diseased states possible? How can disease onset be prevented? These are the two main questions in mind when taking a deeper look into the neuro-genomic profile associated with a particular neurological disease. Analyzing how disease interrupts cellular/molecular pathways gives researchers a window to see where small molecules may be employed for therapeutic purpose. For example, previous work in the lab with HDAC inhibitors and Tau degraders have proved to be successful products of medicinal chemistry. Discovery of new and improved small molecules may continue to probe affected pathways in order to correct downstream ramifications attributable to disease.