Publications

For a complete list of our laboratory's publications, click here.

2022

Differentiation of Human Induced Pluripotent Stem Cells into Cortical Neurons to Advance Precision Medicine.

Silva MC, Nandi G, Haggarty SJ.Methods Mol Biol. 2022;2429:143-174. doi: 10.1007/978-1-0716-1979-7_10.PMID: 35507160

Brain-specific deletion of GIT1 impairs cognition and alters phosphorylation of synaptic protein networks implicated in schizophrenia susceptibility.

Fass DM, Lewis MC, Ahmad R, Szucs MJ, Zhang Q, Fleishman M, Wang D, Kim MJ, Biag J, Carr SA, Scolnick EM, Premont RT, Haggarty SJ.Mol Psychiatry. 2022 May 3. doi: 10.1038/s41380-022-01557-z. Online ahead of print.PMID: 35505090

Discovery and Optimization of Tau Targeted Protein Degraders Enabled by Patient Induced Pluripotent Stem Cells-Derived Neuronal Models of Tauopathy.

Silva MC, Nandi G, Donovan KA, Cai Q, Berry BC, Nowak RP, Fischer ES, Gray NS, Ferguson FM, Haggarty SJ.Front Cell Neurosci. 2022 Mar 3;16:801179. doi: 10.3389/fncel.2022.801179. eCollection 2022.PMID: 35317195 

A bidirectional competitive interaction between circHomer1 and Homer1b within the orbitofrontal cortex regulates reversal learning.

Hafez AK, Zimmerman AJ, Papageorgiou G, Chandrasekaran J, Amoah SK, Lin R, Lozano E, Pierotti C, Dell'Orco M, Hartley BJ, Alural B, Lalonde J, Esposito JM, Berretta S, Squassina A, Chillotti C, Voloudakis G, Shao Z, Fullard JF, Brennand KJ, Turecki G, Roussos P, Perlis RH, Haggarty SJ, Perrone-Bizzozero N, Brigman JL, Mellios N.Cell Rep. 2022 Jan 18;38(3):110282. doi: 10.1016/j.celrep.2021.110282.PMID: 35045295 

2021

Zinc-dependent histone deacetylases drive neutrophil extracellular trap formation and potentiate local and systemic inflammation.

Poli V, Pui-Yan Ma V, Di Gioia M, Broggi A, Benamar M, Chen Q, Mazitschek R, Haggarty SJ, Chatila TA, Karp JM, Zanoni I.iScience. 2021 Oct 11;24(11):103256. doi: 10.1016/j.isci.2021.103256. eCollection 2021 Nov 19.PMID: 34761180 

Targeting Tau Mitigates Mitochondrial Fragmentation and Oxidative Stress in Amyotrophic Lateral Sclerosis.

Petrozziello T, Bordt EA, Mills AN, Kim SE, Sapp E, Devlin BA, Obeng-Marnu AA, Farhan SMK, Amaral AC, Dujardin S, Dooley PM, Henstridge C, Oakley DH, Neueder A, Hyman BT, Spires-Jones TL, Bilbo SD, Vakili K, Cudkowicz ME, Berry JD, DiFiglia M, Silva MC, Haggarty SJ, Sadri-Vakili G.Mol Neurobiol. 2022 Jan;59(1):683-702. doi: 10.1007/s12035-021-02557-w. Epub 2021 Nov 10.PMID: 34757590

Design, Synthesis, and Evaluation of Thienodiazepine Derivatives as Positron Emission Tomography Imaging Probes for Bromodomain and Extra-Terminal Domain Family Proteins.

Bai P, Lan Y, Patnaik D, Wang H, Liu Y, Chen Z, Yuan G, Afshar S, Striar R, Zagaroli JS, Tocci DR, Langan AG, Haggarty SJ, Wang C.J Med Chem. 2021 Oct 14;64(19):14745-14756. doi: 10.1021/acs.jmedchem.1c01323. Epub 2021 Sep 22.PMID: 34549949

High-content image-based analysis and proteomic profiling identifies Tau phosphorylation inhibitors in a human iPSC-derived glutamatergic neuronal model of tauopathy.

Cheng C, Reis SA, Adams ET, Fass DM, Angus SP, Stuhlmiller TJ, Richardson J, Olafson H, Wang ET, Patnaik D, Beauchamp RL, Feldman DA, Silva MC, Sur M, Johnson GL, Ramesh V, Miller BL, Temple S, Kosik KS, Dickerson BC, Haggarty SJ.Sci Rep. 2021 Aug 23;11(1):17029. doi: 10.1038/s41598-021-96227-5.PMID: 34426604 

ELAVL4, splicing, and glutamatergic dysfunction precede neuron loss in MAPT mutation cerebral organoids.

Bowles KR, Silva MC, Whitney K, Bertucci T, Berlind JE, Lai JD, Garza JC, Boles NC, Mahali S, Strang KH, Marsh JA, Chen C, Pugh DA, Liu Y, Gordon RE, Goderie SK, Chowdhury R, Lotz S, Lane K, Crary JF, Haggarty SJ, Karch CM, Ichida JK, Goate AM, Temple S.Cell. 2021 Aug 19;184(17):4547-4563.e17. doi: 10.1016/j.cell.2021.07.003. Epub 2021 Jul 26.PMID: 34314701

Brigatinib causes tumor shrinkage in both NF2-deficient meningioma and schwannoma through inhibition of multiple tyrosine kinases but not ALK.

Chang LS, Oblinger JL, Smith AE, Ferrer M, Angus SP, Hawley E, Petrilli AM, Beauchamp RL, Riecken LB, Erdin S, Poi M, Huang J, Bessler WK, Zhang X, Guha R, Thomas C, Burns SS, Gilbert TSK, Jiang L, Li X, Lu Q, Yuan J, He Y, Dixon SAH, Masters A, Jones DR, Yates CW, Haggarty SJ, La Rosa S, Welling DB, Stemmer-Rachamimov AO, Plotkin SR, Gusella JF, Guinney J, Morrison H, Ramesh V, Fernandez-Valle C, Johnson GL, Blakeley JO, Clapp DW; Synodos for NF2 Consortium.PLoS One. 2021 Jul 15;16(7):e0252048. doi: 10.1371/journal.pone.0252048. eCollection 2021.PMID: 34264955 

Phosphorylation-dependent control of Activity-regulated cytoskeleton-associated protein (Arc) protein by TNIK.

Walczyk-Mooradally A, Holborn J, Singh K, Tyler M, Patnaik D, Wesseling H, Brandon NJ, Steen J, Graether SP, Haggarty SJ, Lalonde J.J Neurochem. 2021 Sep;158(5):1058-1073. doi: 10.1111/jnc.15440. Epub 2021 Jun 22.PMID: 34077555

Exifone Is a Potent HDAC1 Activator with Neuroprotective Activity in Human Neuronal Models of Neurodegeneration.

Patnaik D, Pao PC, Zhao WN, Silva MC, Hylton NK, Chindavong PS, Pan L, Tsai LH, Haggarty SJ.ACS Chem Neurosci. 2021 Jan 20;12(2):271-284. doi: 10.1021/acschemneuro.0c00308. Epub 2021 Jan 8.PMID: 33417763

2020

Tauopathies: Deciphering Disease Mechanisms to Develop Effective Therapies.

Silva MC, Haggarty SJ.Int J Mol Sci. 2020 Nov 25;21(23):8948. doi: 10.3390/ijms21238948.PMID: 33255694 Free PMC article. 

Identification and Mechanistic Characterization of a Peptide Inhibitor of Glycogen Synthase Kinase (GSK3β) Derived from the Disrupted in Schizophrenia 1 (DISC1) Protein.

Saundh SL, Patnaik D, Gagné S, Bishop JA, Lipsit S, Amat S, Pujari N, Nambisan AK, Bigsby R, Murphy M, Tsai LH, Haggarty SJ, Leung AK.ACS Chem Neurosci. 2020 Dec 16;11(24):4128-4138. doi: 10.1021/acschemneuro.0c00380. Epub 2020 Nov 30.PMID: 33253521

Active immunotherapy and alternative therapeutic modalities for Alzheimer's disease.

Weninger S, Sperling B, Alexander R, Ivarsson M, Menzies FM, Powchik P, Weber CJ, Altar CA, Crystal RG, Haggarty SJ, Loring J, Bain LJ, Carrillo MC.Alzheimers Dement (N Y). 2020 Oct 12;6(1):e12090. doi: 10.1002/trc2.12090. eCollection 2020.PMID: 33083513 

Histone deacetylase knockouts modify transcription, CAG instability and nuclear pathology in Huntington disease mice.

Kovalenko M, Erdin S, Andrew MA, St Claire J, Shaughnessey M, Hubert L, Neto JL, Stortchevoi A, Fass DM, Mouro Pinto R, Haggarty SJ, Wilson JH, Talkowski ME, Wheeler VC.Elife. 2020 Sep 29;9:e55911. doi: 10.7554/eLife.55911.PMID: 32990597 

Advances toward precision medicine for bipolar disorder: mechanisms & molecules.

Haggarty SJ, Karmacharya R, Perlis RH.Mol Psychiatry. 2021 Jan;26(1):168-185. doi: 10.1038/s41380-020-0831-4. Epub 2020 Jul 7.PMID: 32636474 

Prolonged tau clearance and stress vulnerability rescue by pharmacological activation of autophagy in tauopathy neurons.

Silva MC, Nandi GA, Tentarelli S, Gurrell IK, Jamier T, Lucente D, Dickerson BC, Brown DG, Brandon NJ, Haggarty SJ.Nat Commun. 2020 Jun 26;11(1):3258. doi: 10.1038/s41467-020-16984-1.PMID: 32591533

HDAC1 modulates OGG1-initiated oxidative DNA damage repair in the aging brain and Alzheimer's disease.

Pao PC, Patnaik D, Watson LA, Gao F, Pan L, Wang J, Adaikkan C, Penney J, Cam HP, Huang WC, Pantano L, Lee A, Nott A, Phan TX, Gjoneska E, Elmsaouri S, Haggarty SJ, Tsai LH.Nat Commun. 2020 May 18;11(1):2484. doi: 10.1038/s41467-020-16361-y.PMID: 32424276

Radiosynthesis and in vivo evaluation of a new positron emission tomography radiotracer targeting bromodomain and extra-terminal domain (BET) family proteins.

Bai P, Lu X, Lan Y, Chen Z, Patnaik D, Fiedler S, Striar R, Haggarty SJ, Wang C.Nucl Med Biol. 2020 May-Jun;84-85:96-101. doi: 10.1016/j.nucmedbio.2020.04.003. Epub 2020 Apr 9.PMID: 32320910

Discovery of suppressors of CRMP2 phosphorylation reveals compounds that mimic the behavioral effects of lithium on amphetamine-induced hyperlocomotion.

Zhao WN, Tobe BTD, Udeshi ND, Xuan LL, Pernia CD, Zolg DP, Roberts AJ, Mani D, Blumenthal SR, Kurtser I, Patnaik D, Gaisina I, Bishop J, Sheridan SD, Lalonde J, Carr SA, Snyder EY, Haggarty SJ.Transl Psychiatry. 2020 Feb 24;10(1):76. doi: 10.1038/s41398-020-0753-6.PMID: 32094324 

A psychiatric disease-related circular RNA controls synaptic gene expression and cognition.

Zimmerman AJ, Hafez AK, Amoah SK, Rodriguez BA, Dell'Orco M, Lozano E, Hartley BJ, Alural B, Lalonde J, Chander P, Webster MJ, Perlis RH, Brennand KJ, Haggarty SJ, Weick J, Perrone-Bizzozero N, Brigman JL, Mellios N.Mol Psychiatry. 2020 Nov;25(11):2712-2727. doi: 10.1038/s41380-020-0653-4. Epub 2020 Jan 27.PMID: 31988434 

TSC patient-derived isogenic neural progenitor cells reveal altered early neurodevelopmental phenotypes and rapamycin-induced MNK-eIF4E signaling.

Martin P, Wagh V, Reis SA, Erdin S, Beauchamp RL, Shaikh G, Talkowski M, Thiele E, Sheridan SD, Haggarty SJ, Ramesh V.Mol Autism. 2020 Jan 6;11(1):2. doi: 10.1186/s13229-019-0311-3. eCollection 2020.PMID: 31921404 

Benzothiazole-Based LRRK2 Inhibitors as Wnt Enhancers and Promoters of Oligodendrocytic Fate.

Zaldivar-Diez J, Li L, Garcia AM, Zhao WN, Medina-Menendez C, Haggarty SJ, Gil C, Morales AV, Martinez A.J Med Chem. 2020 Mar 12;63(5):2638-2655. doi: 10.1021/acs.jmedchem.9b01752. Epub 2019 Dec 26.PMID: 31825616

2019

Response to: X-linked miR-506 family miRNAs promote FMRP expression in mouse spermatogonia.

Ramaiah M, Tan K, Plank TM, Song HW, Dumdie JN, Jones S, Shum EY, Sheridan SD, Peterson KJ, Gromoll J, Haggarty SJ, Cook-Andersen H, Wilkinson MF.EMBO Rep. 2020 Jan 7;21(1):e49354. doi: 10.15252/embr.201949354. Epub 2019 Dec 6.PMID: 31808609 

An Autophagy Modifier Screen Identifies Small Molecules Capable of Reducing Autophagosome Accumulation in a Model of CLN3-Mediated Neurodegeneration.

Petcherski A, Chandrachud U, Butz ES, Klein MC, Zhao WN, Reis SA, Haggarty SJ, Ruonala MO, Cotman SL.Cells. 2019 Nov 27;8(12):1531. doi: 10.3390/cells8121531.PMID: 31783699 

A Comprehensive Resource for Induced Pluripotent Stem Cells from Patients with Primary Tauopathies.

Karch CM, Kao AW, Karydas A, Onanuga K, Martinez R, Argouarch A, Wang C, Huang C, Sohn PD, Bowles KR, Spina S, Silva MC, Marsh JA, Hsu S, Pugh DA, Ghoshal N, Norton J, Huang Y, Lee SE, Seeley WW, Theofilas P, Grinberg LT, Moreno F, McIlroy K, Boeve BF, Cairns NJ, Crary JF, Haggarty SJ, Ichida JK, Kosik KS, Miller BL, Gan L, Goate AM, Temple S; Tau Consortium Stem Cell Group.Stem Cell Reports. 2019 Nov 12;13(5):939-955. doi: 10.1016/j.stemcr.2019.09.006. Epub 2019 Oct 17.PMID: 31631020 

Positron emission tomography probes targeting bromodomain and extra-terminal (BET) domains to enable in vivo neuroepigenetic imaging.

Bai P, Wey HY, Patnaik D, Lu X, Lan Y, Rokka J, Stephanie F, Haggarty SJ, Wang C.Chem Commun (Camb). 2019 Oct 24;55(86):12932-12935. doi: 10.1039/c9cc06734e.PMID: 31599282

Structural Basis for Achieving GSK-3β Inhibition with High Potency, Selectivity, and Brain Exposure for Positron Emission Tomography Imaging and Drug Discovery.

Bernard-Gauthier V, Mossine AV, Knight A, Patnaik D, Zhao WN, Cheng C, Krishnan HS, Xuan LL, Chindavong PS, Reis SA, Chen JM, Shao X, Stauff J, Arteaga J, Sherman P, Salem N, Bonsall D, Amaral B, Varlow C, Wells L, Martarello L, Patel S, Liang SH, Kurumbail RG, Haggarty SJ, Scott PJH, Vasdev N.J Med Chem. 2019 Nov 14;62(21):9600-9617. doi: 10.1021/acs.jmedchem.9b01030. Epub 2019 Oct 21.PMID: 31535859

Kinetic Tuning of HDAC Inhibitors Affords Potent Inducers of Progranulin Expression.

Moreno-Yruela C, Fass DM, Cheng C, Herz J, Olsen CA, Haggarty SJ.ACS Chem Neurosci. 2019 Aug 21;10(8):3769-3777. doi: 10.1021/acschemneuro.9b00281. Epub 2019 Aug 5.PMID: 31330099

Activation of WNT and CREB signaling pathways in human neuronal cells in response to the Omega-3 fatty acid docosahexaenoic acid (DHA).

Zhao WN, Hylton NK, Wang J, Chindavong PS, Alural B, Kurtser I, Subramanian A, Mazitschek R, Perlis RH, Haggarty SJ.Mol Cell Neurosci. 2019 Sep;99:103386. doi: 10.1016/j.mcn.2019.06.006. Epub 2019 Jun 14.PMID: 31202891

Tool inhibitors and assays to interrogate the biology of the TRAF2 and NCK interacting kinase.

Read J, Collie IT, Nguyen-McCarty M, Lucaj C, Robinson J, Conway L, Mukherjee J, McCall E, Donohoe G, Flavell E, Peciak K, Warwicker J, Dix C, Van den Hoven BG, Madin A, Brown DG, Moss S, Haggarty SJ, Brandon NJ, Bürli RW.Bioorg Med Chem Lett. 2019 Aug 1;29(15):1962-1967. doi: 10.1016/j.bmcl.2019.05.032. Epub 2019 May 18.PMID: 31153805

Drug discovery for psychiatric disorders using high-content single-cell screening of signaling network responses ex vivo.

Lago SG, Tomasik J, van Rees GF, Steeb H, Cox DA, Rustogi N, Ramsey JM, Bishop JA, Petryshen T, Haggarty SJ, Vázquez-Bourgon J, Papiol S, Suarez-Pinilla P, Crespo-Facorro B, van Beveren NJ, Bahn S.Sci Adv. 2019 May 8;5(5):eaau9093. doi: 10.1126/sciadv.aau9093. eCollection 2019 May.PMID: 31086815

Deep Learning Benchmarks on L1000 Gene Expression Data.

McDermott MBA, Wang J, Zhao WN, Sheridan SD, Szolovits P, Kohane I, Haggarty SJ, Perlis RH.IEEE/ACM Trans Comput Biol Bioinform. 2020 Nov-Dec;17(6):1846-1857. doi: 10.1109/TCBB.2019.2910061. Epub 2020 Dec 8.PMID: 30990190 Free

A farnesyltransferase inhibitor activates lysosomes and reduces tau pathology in mice with tauopathy.

Hernandez I, Luna G, Rauch JN, Reis SA, Giroux M, Karch CM, Boctor D, Sibih YE, Storm NJ, Diaz A, Kaushik S, Zekanowski C, Kang AA, Hinman CR, Cerovac V, Guzman E, Zhou H, Haggarty SJ, Goate AM, Fisher SK, Cuervo AM, Kosik KS.Sci Transl Med. 2019 Mar 27;11(485):eaat3005. doi: 10.1126/scitranslmed.aat3005.PMID: 30918111

Targeted degradation of aberrant tau in frontotemporal dementia patient-derived neuronal cell models.

Silva MC, Ferguson FM, Cai Q, Donovan KA, Nandi G, Patnaik D, Zhang T, Huang HT, Lucente DE, Dickerson BC, Mitchison TJ, Fischer ES, Gray NS, Haggarty SJ.Elife. 2019 Mar 25;8:e45457. doi: 10.7554/eLife.45457.PMID: 30907729

Human pluripotent stem cell-derived models and drug screening in CNS precision medicine.

Silva MC, Haggarty SJ.Ann N Y Acad Sci. 2020 Jul;1471(1):18-56. doi: 10.1111/nyas.14012. Epub 2019 Mar 15.PMID: 30875083

A microRNA cluster in the Fragile-X region expressed during spermatogenesis targets FMR1.

Ramaiah M, Tan K, Plank TM, Song HW, Dumdie JN, Jones S, Shum EY, Sheridan SD, Peterson KJ, Gromoll J, Haggarty SJ, Cook-Andersen H, Wilkinson MF.EMBO Rep. 2019 Feb;20(2):e46566. doi: 10.15252/embr.201846566. Epub 2018 Dec 20.PMID: 30573526

PET neuroimaging reveals histone deacetylase dysregulation in schizophrenia.

Gilbert TM, Zürcher NR, Wu CJ, Bhanot A, Hightower BG, Kim M, Albrecht DS, Wey HY, Schroeder FA, Rodriguez-Thompson A, Morin TM, Hart KL, Pellegrini AM, Riley MM, Wang C, Stufflebeam SM, Haggarty SJ, Holt DJ, Loggia ML, Perlis RH, Brown HE, Roffman JL, Hooker JM.J Clin Invest. 2019 Jan 2;129(1):364-372. doi: 10.1172/JCI123743. Epub 2018 Dec 10.PMID: 30530989

Identification of evolutionarily conserved gene networks mediating neurodegenerative dementia.

Swarup V, Hinz FI, Rexach JE, Noguchi KI, Toyoshiba H, Oda A, Hirai K, Sarkar A, Seyfried NT, Cheng C, Haggarty SJ; International Frontotemporal Dementia Genomics Consortium, Grossman M, Van Deerlin VM, Trojanowski JQ, Lah JJ, Levey AI, Kondou S, Geschwind DH.Nat Med. 2019 Jan;25(1):152-164. doi: 10.1038/s41591-018-0223-3. Epub 2018 Dec 3.PMID: 30510257